Home Contact Us Search Toxic Exposure Study Trust Foundation

Thimerosal Toxicity

Mercury Amalgam Thimerosal Founders Donations

Thimerosal Toxicity
Neurotoxicity
Thimerosal Content
Published  Studies
Thimerosal Vs. Hg(II)
Vaccine Hg Exposure
FDA Hypocracy
Experts Speak Out
Vaccines & Development
IOM Conference
Neurodevelopmental Effects
Autism & Mercury
Thimerosal Links
Mothering & Autism
Homeland Insecurity
Records Sealed
Government Knew
Known Effects
Vaccine Lawsuits
Eli Lilly & Thimerosal
Vaccine Booster
Hg Free Vaccines
Vaccine Assessment
Metals & Autism
Congressional Acts
WHO & Thimerosal
Flu Vaccines
Autism & Vaccines
Autism & Detoxification
Childhood Immunizations
Aluminum & Vaccines
Vaccine Adjuvants
Allergic Components
Thimerosal & Autism
AAPS Opposition
Toxic Vaccines
Mercury Exposure
Hg in Medicines
Vaccines-Pro & Con
Candida & Autism
Thimerosal Effects
Gulf War Syndrome
Dr. Synder Responds
Myth From Reality
Vaccine History
Developmental Disorders
CDC's NIP
Polio Vaccine
Smallpox
Chickenpox
Safe Minds
Why So Long?
1st Vaccine Conference
2nd Vaccine Conference
Vaccine Injury
MMR and IBD
 

Thimerosal - Harmless Vaccine Preservative Or Just Another Toxic Organic Mercury Compound?


5/18/2000

Click here to start

Table of Contents

  1. Thimerosal - Harmless Vaccine Preservative Or Just Another Toxic Organic Mercury Compound?

  2. Thimerosal Synonyms

  3. Structure of Thimerosal

  4. Thimerosal Physical & Chemical Properties

  5. Thimerosal Is Composed of Thiosalicylic Acid And Ethyl Mercury, A Known Toxicant

  6. Why All The Concern About The Safety Of Thimerosal And Why Now?

  7. The Food And Drug Administration’s Response To FDAMA

  8. By The First Grade Children In The U.S. Receive 21 Vaccinations, Many Of Which Contain Thimerosal

  9. PPT Slide

  10. Vaccines And Immunoglobulins Which Contain Thimerosal

  11. Vaccines And Immunoglobulins Which Contain Thimerosal

  12. “Limiting Infant Exposure to Thimerosal in Vaccines and Other Sources of Mercury.” Neal A. Halsey, MD (1999). JAMA 282:1763-1766.

  13. Joint Statement Of The American Academy of Pediatrics (AAP) And The Public Health Service (PHS) On July 7, 1999 Regarding The Use And Safety Of Thimerosal In Vaccines.

  14. Joint Statement Of The American Academy of Pediatrics (AAP) And The Public Health Service (PHS) On July 7, 1999 Regarding The Use And Safety Of Thimerosal In Vaccines.

  15. Joint Statement Of The American Academy of Pediatrics (AAP) And The Public Health Service (PHS) On July 7, 1999 Regarding The Use And Safety Of Thimerosal In Vaccines.

  16. Joint Statement Of The American Academy of Pediatrics (AAP) And The Public Health Service (PHS) On July 7, 1999 Regarding The Use And Safety Of Thimerosal In Vaccines.

  17. Chemicals And Substances Found In Vaccines

  18. In Vitro Toxicity Studies of Thimerosal

  19. Experimental Protocol For Comparing Thimerosal Toxicity Against That Of HgCl2 Using Nucleotide Photoaffinity Labeling

  20. Schematic Diagram Showing How Cysteine Sulfhydryl (-SH) Groups Are Critical to the Activity of Many Nucleotide Binding Proteins (NBPs)

  21. These Critical Cysteine Sulfhydryl (-SH) Groups Are Often Involved In The Nucleotide And/Or Substrate Binding Required For Enzymatic Activity

  22. Sulfhydryl Reactive Heavy Metals Such as Mercury (Hg2+) and Mercury Containing Compounds Can Bind To Active Site Cysteines And Inhibit Enzyme Activity

  23. Reported Neurotoxic Effects Of Thimerosal On Brain Nucleotide Binding Proteins

  24. Reported Toxic Effects Of Thimerosal On Tubulin

  25. Thimerosal Disrupts The Microtubule Spindle Apparatus Causing Chromosome Aberrations

  26. Toxicant Induced Decreases In Enzyme Activity Can Be Detected & Quantified Using Photoaffinity Labeling

  27. SDS-PAGE Analysis Of Brain Homogenate Proteins Treated With Increasing Concentrations Of HgCl2 Or Thimerosal Prior To Photolabeling With [32P]8N3GTP

  28. At Equimolar Concentrations, HgCl2 Is A More Potent Inhibitor Of [32P]8N3GTP-b-Tubulin Interactions Than Is Thimerosal In Crude Brain Homogenate

  29. SDS-PAGE Analysis of Brain Homogenate Proteins Treated with Increasing Concentrations of Thimerosal Vs. 5µM HgCl2 Prior To Photolabeling with [32P]GTP-Azidoanilide

  30. Autoradiogram Showing That An 8-Fold Greater Concentration Of Thimerosal Is Required To Inhibit [32P]GTP-AA Photolabeling Of Brain b-Tubulin To The Same Extent As 5 µM HgCl2

  31. SDS-PAGE Analysis of Brain Homogenate Proteins Treated With Increasing Concentrations Of Thimerosal Vs. 5µM HgCl2 Prior To Photolabeling With [32P]8N3GTP

  32. Autoradiogram Showing That An 8-10 Fold Greater Concentration of Thimerosal Is Required To Inhibit [32P]8N3GTP Photolabeling of Brain b-Tubulin To The Same Extent As 5 µM HgCl2

  33. SDS-PAGE Analysis Of Brain Homogenate Proteins Treated With Increasing Concentrations Of Thiosalicylate Vs. 60µM Thimerasol Prior To Photolabeling with [32P]GTP-Azidoanilide

  34. Thimerasol Inhibition Of [32P]8N3GTP Photolabeling Of b-Tubulin In Crude Brain Homogenate Is Not Due To The Thiosalicylate Portion Of The Molecule

  35. SDS-PAGE Analysis Of Purified Bovine Brain Tubulin Treated With Increasing Concentrations Of HgCl2 Vs. Thimerosal Prior To Photolabeling with [32P]GTP-Azidoanilide

  36. In Contrast To Crude Brain Homogenate, Thimerosal Is Just As Potent An Inhibitor of [32P]GTP-Azidoanilide Photolabeling of Purified Brain Tubulin As Is HgCl2

  37. Possible Explanation For These Apparently Conflicting Results Between The Toxic Effects Of Thimerosal On Brain b-Tubulin

  38. SDS-PAGE Analysis Of Purified Mammalian Enzymes Treated With Increasing Concentrations Of Thimerosal Vs. 5µM HgCl2 Prior To Photolabeling With [32P]2N3ATP

  39. Autoradiogram Showing That Thimerosal Is A Much More Potent Inhibitor Of [32P]2N3ATP Photolabeling Of Purified Mammalian Enzymes Than Is HgCl2

  40. SDS-PAGE Analysis Of Purified Mammalian Enzymes Treated With Increasing Concentrations Of Thiosalicylate Vs. Thimerosal Vs. HgCl2 Prior To [32P]2N3ATP Photolabeling

  41. Autoradiogram Showing That Thimerosal Is A More Potent Inhibitor Of [32P]2N3ATP Photolabeling Of Purified Mammalian Enzymes Than Is HgCl2 And Inhibition Is Not Due To Thiosalicylate

  42. Conclusions

  43. Hypothesis-Exposure To Drugs and Toxicants During Times Of Stress Increases Their Toxic Potential

  44. “The Gulf War, Stress And A Leaky Blood-Brain Barrier.” Israel Hanin, (1996). Nature Medicine 2:1307-1308.

  45. The Gulf War, Stress And A Leaky Blood-Brain Barrier. Israel Hanin, (1996). Nature Medicine 2:1307-1308.

Author: J. Curt Pendergrass, Ph.D.

President, ALT Inc.

 

Home Up Next